UT Dallas Syllabus for nsc4352.001 05f taught by Michael Kilgard (kilgard)

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C e l l u l ar N eurosc i ence S y ll a b us (N S C - 4 3 5 2 ) Instructor: Dr. Michael P. Kilgard Office: JonssonJO4.304 Office Hours:\ue000 Thursday 10:45-11:45pm Office Phone: (972) 883-2339 E-mail Address: kilgard@utdallas.edu Teaching Assistant:\ue000 Vikram Jakkamsetti Office: GR 4.604 E-mail Address:vxj037000@utdallas.edu Weekly Review: GR 3.302 Tuesday 4-5pm Class Time: Tuesday and Thursday 9:30-10:45 Class Location: GR 4.301 Required Texts: Principles of Neural Science, 4th ed. (Kandel, Schwartz & Jessell) [K] Neuroscience, 3rd ed.\ue000 (Purves et al.) [P]. Both should be available at Off-Campus Books (Campbell Rd.) & the UTD bookstore. Recommended text:\ue000 Neurons in Action (order from www.sinauer.com) Course Description This course will cover the major issues of cellular neuroscience. Recent advances in the understanding of the molecular and cellular events underlying neural signaling, synaptic transmission, neural development, and plasticity will be discussed. Assessment Exams (90%): There will be two exams (25% each) and a cumulative final exam (40%). Exams will be multiple choice and short answer. Material for these exams will be taken from readings, class lectures and discussion, so attendance is strongly encouraged. The format of the exam questions is designed to be challenging and to encourage integrative thought about the material. Exams will be curved such that the second highest score receives 100%. Questions (15%): One week before each exam, each student will be expected to generate 5 complete multiple-choice exam questions including multiple answers with the correct answer indicated. Up to 5 points will be earned based on the quality of the questions. Five points is guaranteed if one of your questions is used on an exam. (Note: questions may be somewhat altered.) Final Grade: A: 105-90, B: 89-80, C: 79-70, Less than 70% is failing. \ue000\ue000S c h e d u le : Additional papers related to temporal processing and learning: ã Decoding temporal information: A model based on short -term synaptic plasticity . – J Neurosci. 2000 Feb 1;20(3):1129 -41. ã Context-sensitive synaptic plasticity and temporal-to-spatial transformations in hippocampal slices . – Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10403 -8. (For complete papers follow the links above and click on blue box labeled ‘free full text ’.) Any schedule changes will be posted at:www.utdallas.edu/~kilgard/cellularFALL05.htm Click here for the Final Exam Review Outline.  DATE TOPIC ASSIGNMENTS 8/18 Introductory lecture - Neural Perspectives  8/23 Intro to Neurons Purves Ch1 (1-5); Kandell Ch2 8/25 C y tolo g y of Neurons Kandell Ch3 8/30 Protein Sorting Kandell Ch4 9/1 Genes and Behavior Purves 2 9/6 Membrane potential Kandell Ch5 9/8 Membrane potential, con't Kandell Ch6, Neurons in Action (optional) 9/13 Passive Current Flow Kandell Ch7 9/15 Action Potential Purves Ch3, 4 9/20 Action potential, con't Kandell Ch8, Neurons in Action (optional) 9/22 Catch-up Neurons in Action (optional) Exam Questions Due 9/27 Review for Exam  9/29 EXAM(25%)  10/4 Synaptic Release Purves Ch5, Kandell Ch9 10/6 Neuromuscular Junction Kandell Ch10 10/11 Synaptic Integration Kandell Ch11, Neurons in Action (optional) 10/13 Transmitter Release Kandell Ch13, 15 10/18 Neurotransmitters Purves Ch6, Kandell Ch14 10/20 Neurotransmitter Receptors and Their Effects Purves Ch7 10/25 Intracellular Signaling Kandell Ch12, Purves Ch8  10/27 Myasthenia Gravis Kandell Ch16, Exam Questions Due 11/1 Review for Exam  11/3 EXAM(25% )  11/8 Synaptic Plasticity Kandell Ch63 11/10 Adult Plasticity and Learning Purves Ch25 11/15 Primary Research Paper Buonomano DV, et al Temporal information transformed into a spatial code by a neural network with realistic properties. Science. 1995 Feb 17;267(5200):1028-30. (figure 2) Exam Questions Due 11/17 Review for Final  12/1 FINAL EXAM(40%) 8:00am-10:30am
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