DNA Dan RNA Kelompok 6- Kimia Organik

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pengertian, struktur, sifat DNA dan RNA
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  KIMIA ORGANIK DNA DAN RNA Disusun oleh :1.Mazida Zulfah Alfit220103161400062.Nurin Sabrina D220103161400223.Putriani !atnasari2201031614002 4.#u$nia !ah$a%ati22010316140033&.'as$ine !e(ita Putri2201031614003 6.Mirani )ali$a22010316140040 PROGRAM STUDI FARMASIFAKULTAS KEDOKTERAN UNIVERSITAS DIPONEGOROSEMARANG2017  1.1.!NA1.1.1.Stru*tur !NA!NA $eru+a*an +oli$er +an,an( an( terdiri dari nu*leotida - nu*leotidaan( bersa$bun( den(an i*atan 3 →  & fosfodiester. Stru*tur *o/alen !NA berbeda den(an DNA dala$ dua hal. Seba(ai$ana terbaa dari na$ana unit-unit (ula dala$ !NA beru+a ribosa bu*an deo*siribosa di$ana +ada !NA ato$ no$or 2 beri*atan den(an (u(us hidro*sil )5. !ibosa $en(andun( sebuah(u(us 2-hidro*sil an( tida* terda+at deo*siribosa. asa nitro(en an( terda+at +ada !NA tersusun atas adenine  A5  gunanine  75 uracil   85 dan cytosine  5.8rasil se+erti ti$in da+at $e$bentu* +asan(an basa den(an adenin. Guanine  ber+asan(an den(an cytosyne . Pasan(an basa da+at beri*atan di*arena*an adanai*atan hidro(en 9ee dan 7utel. 20045. 1.1.2.Sifat !NASifat !NA da+at dilihat berdasar*an ti+e  ti+e !NA. !NA diba(i $en,adi 3 ti+eaitu :1.;ransfer !NA t-!NA5  ;ransfer !NA t- !NA5 $eru+a*an bentu* ter*eil dari !NA. <arenau*uranna $a*a *adan( disebut s-!NA s$all-!NA5 seba(ai a*ibat bah%aia tin((al di dala$ airan ba(ian atas dari larutan sedan(*an bentu* !NAan( lain an( lebih berat5 $en(enda+ oleh sentrifu(asi ultra. Masin($asin(dari *e-20 asa$ a$ino $e$+unai sedi*itna satu $ole*ul t-!NA isti$e%aan( ber(una untu* $en(an(*ut $ole*ul t-!NA tadi *e te$+at sintesis +rotein dan $en,a$in +ene$+atanna an( benar dala$ urutan asa$ a$inodari +rotein an( sedan( disintesis. Anti*odon $e$ain*an +eranan *unidala$ sintesis +rotein. 2. Messen(er !NA $-!NA5 8*uran $ole*ul $-!NA ter(antun( +ada ,u$lah sisa asa$ a$ino dala$ +rotein an( $e$erlu*an $ole*ul $-!NA itu seba(ai eta*an. Sintesis suatu +rotein an( $en(andun( sisa asa$ a$ino sebana* &00 ,elas harus diurusoleh $ole*ul $-!NA an( $e$+unai sedi*itna 1&00 3 ×  &00 basa5.3.!iboso$al !NA $-!NA5 Sintesis +rotein ter,adi di atas +er$u*aan !NA-+rotein *o$+le*s an(di*enal seba(ai riboso$. Seluruh fun(si riboso$ adalah $en,a$in orientasian( benar antara eta*an $-!NA dan $ole*ul-$ole*ul a$onosil t-!NA an(sedan( dii*at*an *e+ada eta*an. <arena itu riboso$ seara *husus $en(i*at$-!NA a$inosil t-!NA an( datan( $asu* dan ba(ian dari rantai an(sedan( tu$buh se$uana +ada orientasi stero*i$ia%i an( betul. ;a$bahan +ula riboso$ $en(andun( enzi$-enzi$ tertentu disebut translo*ase an($enebab*an riboso$ ber(era* se+an,an( untai $-!NA se%a*tu sintesis +rotein berlan(sun( a$+bell NA et. al. 20045.1.1.3.;rans*ri+si;rans*ri+si $enan(*ut +eran(*aian seara linier satuan-satuan $ono$er !NA.atau ribo-nu*leotida den(an $en((una*an suatu ba(ian *has an( *eil (ene5dari untaian DNA seba(ai $odel. Mole*ul !NA tida* sa,a $enedia*an eta*an*er,a ba(i biosintesis +rotein teta+i ,u(a be*er,a seba(ai +e$ba%a isti$e%a  untu* asa$ a$ino serta ,u(a $e$+erlen(*a+i te$+at tautan di $ana sintesis +rotein a*an berlan(sun( <iss. 20015.
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